- Mechanism: Mitochondrial dysfunction is a key player in neurodegenerative diseases like Alzheimer’s and Parkinson’s. Preclinical research has focused on compounds that protect mitochondria from damage, reducing oxidative stress and inflammation in brain cells. One example is elamipretide, which has been shown to improve mitochondrial function and prevent neuron loss.
- Results: In animal models, these compounds have been effective in reducing cognitive decline with minimal side effects.
- Current Stage: These compounds are still in preclinical development but show promise as a treatment for dementia and other neurodegenerative diseases.
https://www.sciencedaily.com/releases/2024/01/240129182418.htm#google_vignette